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Biologic Publications

Biological treatment of the knee with platelet-rich plasma or bone marrow aspirate concentrates

Knee pathologies including focal cartilage injuries, osteoarthritis and ligament injuries are common. The use of biologic agents has emerged as an option for treating these diseases. Platelet-rich plasma (PRP) has gained significant interest for treating common sports medicine more

Biologic Publications

The Role of Orthobiologics in the Management of Osteoarthritis and Focal Cartilage Defects

This study talks about newer biologic treatments in use to potentially slow disease progression in patients with knee osteoarthritis. These include hyaluronic acid, platelet-rich plasma (PRP), bone-marrow aspirate concentrate (BMAC) and adipose-derived mesenchymal stem cells. Believed to affect more

Biologic Publications

Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis

This study discusses the effects of mesenchymal stem cells (MSCs) on cartilage regeneration and patient-reported pain and function. Osteoarthritis (OA) is one of the most common causes of joint pain and disability; MSCs have been extensively studied as more

Biologic Publications

Rationale for Biologic Augmentation of Rotator Cuff Repairs

This study reviews the current evidence surrounding rotator cuff repairs (RCR). Rotator cuff tears are a frequent cause of shoulder pain and disability; despite resolution of pain and outcome measures following surgery, incomplete healing or re-tearing following surgery more

Biologic Publications

Preparation Methods and Clinical Outcomes of Platelet-Rich Plasma for Intra-articular Hip Disorders

Hip preservation treatments have become increasingly investigated in the past few decades. Particularly with the advent of orthobiologics, such as platelet-rich plasma (PRP) and stem cells, common intra-articular hip pathologies are now managed with injections. However, as studies more

Biologic Publications

Ortho-Biologics for Ligament Repair and Reconstruction

This study talks about the role of biologics in common ligament injuries. There is a significant potential with the use of biologics given it may enhance tissue healing. Biologics may provide an alternative to surgical intervention when nonoperative more

Biologic Publications

Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis

This study evaluates the current literature on the safety and efficacy of intra-articular cellular therapy injections. For patients with osteoarthritis or focal cartilage defects, intra-articular cellular therapy is appealing in that it may help with cartilage regeneration. The more

Biologic Publications

Concentrated Bone Marrow Aspirate for the Treatment of Chondral Injuries and Osteoarthritis of the Knee: A Systematic Review of Outcomes

This study talks about outcomes following the use of bone marrow aspirate concentrate (BMAC) in patients with knee osteoarthritis and cartilage defects. BMAC has emerged as an important biological tool for the orthopaedic surgeon because it is one more

Biologic Publications

Biologic Options for Articular Cartilage Wear (Platelet-Rich Plasma, Stem Cells, Bone Marrow Aspirate Concentrate)

This article reviews biological treatment options for articular cartilage repair, including platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC) and cell-based therapies. Articular cartilage damage is seen most commonly in focal chondral lesions and early osteoarthritis and is more

Biologic Publications

Adipose-Derived Mesenchymal Stem Cell Treatments and Available Formulations

This article reviews the current literature surrounding the use of human adipose-derived mesenchymal stem cells (ADSCs) in the management of various orthopedic diseases. ADSCs have gained attention due to their potential for expediting healing and the ease of more